Role of Müller cells in pathogenesis of retinal diseases

doi:10.3760/ cma.j.issn.1673-5803.2022.02.015

International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (2): 179-184.doi: 10.3760/ cma.j.issn.1673-5803.2022.02.015

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Role of Müller cells in pathogenesis of retinal diseases

Zhang Yue, Liu Hanruo

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China

Received:2021-05-07 Online:2022-04-22 Published:2022-04-24
Contact: Liu Hanruo, Email: hanruo.liu@hotmail.co.uk
Supported by:
National Natural Science Fundation of China (81700813); Beijing Science and Technology Rising Star Project (Z191100001119072)

Abstract

Abstract: Müller cells are a kind of glial cells in the retina and responsible for the stability of the retinal structure and the protection of neurons, with the functions of regulating water and electrolyte balance, maintaining neurotransmitter homeostasis, regulating immune and inflammatory responses and regulating the activity of retinal neurons. When the retina is damaged, Müller cells will undergo reactive gliosis, which might be neuroprotective or neurodegenerative. The gliosis process is related to diabetic retinopathy, proliferative vitreoretinopathy, retinal detachment, ischemia, hypoxia and other retinal diseases. (Int Rev Ophthalmol, 2022, 46: 179-184)

Key words: Müller cell, gliosis, diabetic retinopathy, proliferative vitreoretinopathy, retinal detachment　　

Zhang Yue, Liu Hanruo. Role of Müller cells in pathogenesis of retinal diseases[J]. International Review of Ophthalmology, 2022, 46(2): 179-184.

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Role of Müller cells in pathogenesis of retinal diseases

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